BioTechMed-Graz Flagship Lecture mit Prof. Andreas Bäumler

Wir laden Sie herzlich zum nächsten BioTechMed-Graz Faculty Club am Mittwoch, 17.04.2019 um 17 Uhr ein (Stremayrgasse 16, Hörsaal BMT).

Prof. Andreas Bäumler (Department of Medical Microbiology and Immunology, University of California Davis School of Medicine) wird eine Flagship Lecture zum Thema “Healthy guts exclude oxygen” halten. Untenstehend finden Sie nähere Informationen zu seinem Vortrag.

Im Anschluss gibt es wie gewohnt die Gelegenheit zu informellem Austausch bei einem kleinen Buffet in der „Mensa Rooftop an der TU Graz“ im fünften Stock.

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Flagship Lecture Prof. Bäumler, 17.04.2019:

An imbalance in the colonic microbiota might underlie many human diseases, but the mechanisms maintaining homeostasis remain elusive. Recent insights suggest that colonocyte metabolism functions as a control switch, mediating a shift between homeostatic and dysbiotic communities. During homeostasis, colonocyte metabolism is directed towards oxidative phosphorylation, resulting in high epithelial oxygen consumption. The consequent epithelial hypoxia helps maintain a microbial community dominated by obligate anaerobic bacteria, which provide benefit by converting fiber into fermentation products absorbed by the host. Conditions that alter the metabolism of the colonic epithelium increase epithelial oxygenation, thereby driving an expansion of facultative anaerobic bacteria, a hallmark of dysbiosis in the colon. Enteric pathogens subvert colonocyte metabolism to escape niche protection conferred by the gut microbiota. The reverse strategy, a metabolic reprogramming to restore colonocyte hypoxia, represents a promising new therapeutic approach for rebalancing the colonic microbiota in a broad spectrum of human diseases.